Jump to main content
Jump to site search


Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

Author affiliations

Abstract

The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)2 mediated regioselective, direct C–H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies.

Graphical abstract: Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Nov 2017, accepted on 01 Feb 2018 and first published on 01 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC08588E
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant

    N. Viswanadh, G. S. Ghotekar, M. B. Thoke, R. Velayudham, A. C. Shaikh, M. Karthikeyan and M. Muthukrishnan, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08588E

Search articles by author

Spotlight

Advertisements