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Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

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Abstract

Reported herein is an oxidative coupling reaction of an α-C(sp3)–H bond of amine with a benzylic C(sp3)–H bond through Mn or Co catalysis to provide diverse collections of α-tertiary β-arylethylamines. This protocol features an easily installed and removable coordinating activation group, a wide scope of substrates, low-cost metal catalysts, easily available starting materials and synthetic simplicity.

Graphical abstract: Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

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Publication details

The article was received on 05 Nov 2017, accepted on 08 Jan 2018 and first published on 08 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08512E
Citation: Chem. Commun., 2018, Advance Article
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    Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

    M. Tan, K. Li, J. Yin and J. You, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08512E

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