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DNAzyme based visual detection of DNA methylation

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Abstract

A novel colorimetric method which utilizes DNAzyme as a signal reporter was developed for DNA methylation detection. As low as 1/106 of methylated DNA could be successfully detected from unmethylated DNA. The discrimination ability is at least two orders of magnitude better than that of the methylation specific PCR.

Graphical abstract: DNAzyme based visual detection of DNA methylation

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Publication details

The article was received on 02 Nov 2017, accepted on 28 Nov 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08427G
Citation: Chem. Commun., 2018, Advance Article
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    DNAzyme based visual detection of DNA methylation

    M. Li, L. Zhang, G. Chen, J. Zhou, Y. Yuan, J. Zou, M. Yuan, R. Chen, F. Du, X. Cui, X. Huang, J. Dong and Z. Tang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08427G

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