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Branched peptides for enzymatic supramolecular hydrogelation

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Abstract

Here we show the use of branched peptides (i.e., isopeptides) as the substrates of proteases for generating supramolecular hydrogels via enzymatically clipping the branch off the peptides. As the first report of using a protease to cut branched peptides to enable a molecular process for converting nanostructures, this work illustrates a fundamentally new molecular motif for exploring the applications of protease-instructed self-assembly for soft materials.

Graphical abstract: Branched peptides for enzymatic supramolecular hydrogelation

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Publication details

The article was received on 01 Nov 2017, accepted on 21 Nov 2017 and first published on 06 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08421H
Citation: Chem. Commun., 2018, Advance Article
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    Branched peptides for enzymatic supramolecular hydrogelation

    H. He, H. Wang, N. Zhou, D. Yang and B. Xu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08421H

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