Aldehyde-functionalized metal–organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids

Jian Wang; Yanhong Liu; Min Jiang; Yang Li; Lingling Xia; Pengyan Wu

doi:10.1039/C7CC08414E

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Aldehyde-functionalized metal–organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids†

Jian Wang,

^a Yanhong Liu,^a Min Jiang,^a Yang Li,^a Lingling Xia^a and Pengyan Wu*^a

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* Corresponding authors

^a School of Chemistry and Materials Science & Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu, China
E-mail: wpyan@jsun.edu.cn

Abstract

A novel aldehyde-functionalized porous metal–organic framework (MOF) material has been constructed that can act as the first example of MOF-implicated sensors for discriminating Hcy from natural amino acids and even thiol-related peptides (GSH) with high sensitivity (LOD = 40 nM). The sensing mechanism is also discussed.

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DOI: https://doi.org/10.1039/C7CC08414E
Article type: Communication
Submitted: 01 Nov 2017
Accepted: 03 Jan 2018
First published: 03 Jan 2018

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Chem. Commun., 2018,54, 1004-1007

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Aldehyde-functionalized metal–organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids

J. Wang, Y. Liu, M. Jiang, Y. Li, L. Xia and P. Wu, Chem. Commun., 2018, 54, 1004 DOI: 10.1039/C7CC08414E

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Chemical Communications

Aldehyde-functionalized metal–organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids†

Abstract

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Aldehyde-functionalized metal–organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids

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