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Issue 6, 2018
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Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics

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Abstract

The binding of Au(III) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.

Graphical abstract: Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics

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Publication details

The article was received on 01 Nov 2017, accepted on 19 Dec 2017 and first published on 19 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08406D
Citation: Chem. Commun., 2018,54, 611-614
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    Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics

    M. N. Wenzel, S. M. Meier-Menches, T. L. Williams, E. Rämisch, G. Barone and A. Casini, Chem. Commun., 2018, 54, 611
    DOI: 10.1039/C7CC08406D

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