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Issue 8, 2018
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Organocatalytic asymmetric synthesis of 2,4-disubstituted imidazolidines via domino addition-aza-Michael reaction

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Abstract

The first highly diastereo- and enantioselective synthesis of 2,4-disubstituted imidazolidines has been developed via a formal [3+2] cyclization reaction. Bidentate aminomethyl enones and N-tosyl imines were used as the reaction partners in the reaction. Bifunctional squaramide catalysts were found to be efficient for this reaction and few transformations of the products have been demonstrated.

Graphical abstract: Organocatalytic asymmetric synthesis of 2,4-disubstituted imidazolidines via domino addition-aza-Michael reaction

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Publication details

The article was received on 30 Oct 2017, accepted on 03 Jan 2018 and first published on 03 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08338F
Citation: Chem. Commun., 2018,54, 964-967
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    Organocatalytic asymmetric synthesis of 2,4-disubstituted imidazolidines via domino addition-aza-Michael reaction

    S. Mukhopadhyay and S. C. Pan, Chem. Commun., 2018, 54, 964
    DOI: 10.1039/C7CC08338F

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