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Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

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Abstract

Methyltransferases are powerful tools for site-specific transfer of non-natural functional groups from synthetic analogs of their cosubstrate S-adenosyl-L-methionine (AdoMet). We present a new class of AdoMet analogs containing photo-caging (PC) groups in their side chain, enzymatic transfer of PC groups by a promiscuous DNA MTase as well as light-triggered removal from the target DNA. This strategy provides a new avenue to reversibly modulate the functionality of DNA at MTase target sites.

Graphical abstract: Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

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Publication details

The article was received on 27 Oct 2017, accepted on 23 Nov 2017 and first published on 24 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08300A
Citation: Chem. Commun., 2018, Advance Article
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    Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

    L. Anhäuser, F. Muttach and A. Rentmeister, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08300A

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