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Issue 6, 2018
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Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

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Abstract

A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.

Graphical abstract: Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

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Publication details

The article was received on 30 Oct 2017, accepted on 21 Dec 2017 and first published on 21 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08286J
Citation: Chem. Commun., 2018,54, 658-661
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    Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

    D. Bouzada, I. Salvadó, G. Barka, G. Rama, J. Martínez-Costas, R. Lorca, Á. Somoza, M. Melle-Franco, M. E. Vázquez and M. Vázquez López, Chem. Commun., 2018, 54, 658
    DOI: 10.1039/C7CC08286J

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