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Issue 12, 2018
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Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

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Abstract

We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

Graphical abstract: Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

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Publication details

The article was received on 26 Oct 2017, accepted on 20 Dec 2017 and first published on 03 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08242H
Citation: Chem. Commun., 2018,54, 1417-1420
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    Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

    J. A. Rabinowitz, J. C. Lainson, S. A. Johnston and C. W. Diehnelt, Chem. Commun., 2018, 54, 1417
    DOI: 10.1039/C7CC08242H

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