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Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

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Abstract

Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.

Graphical abstract: Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

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Publication details

The article was received on 25 Oct 2017, accepted on 03 Jan 2018 and first published on 03 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08222C
Citation: Chem. Commun., 2018, Advance Article
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    Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

    X. Wang, X. Li, A. Ito, Y. Sogo, Y. Watanabe, K. Hashimoto, A. Yamazaki, T. Ohno and N. M. Tsuji, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08222C

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