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Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

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Abstract

Continuous processing of pharmaceuticals opens opportunities for continuous separation based on wettability of polymer membranes. Dual use of hydrophobic and hydrophilic membranes realize in-line liquid–liquid extraction in the synthesis of four essential APIs. A secondary membrane with opposite wetting characteristics proves critical to phase separation of aqueous–organic reaction streams.

Graphical abstract: Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

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Publication details

The article was received on 24 Oct 2017, accepted on 28 Nov 2017 and first published on 28 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08218E
Citation: Chem. Commun., 2018, Advance Article
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    Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

    J. Imbrogno, L. Rogers, D. A. Thomas and K. F. Jensen, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08218E

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