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Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release

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Abstract

Herein, we designed and prepared a photoresponsive spherical nucleic acid (SNA) conjugate by inserting a photocleavable linker into the recognition sequence of SNA which can block the reactivity of the system temporally until specific UV light (∼365 nm) is introduced. The photoresponsive SNA realizes temporal regulation of a self-assembly reaction circuit and spatial selectivity of microRNA release in a cell population, respectively.

Graphical abstract: Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release

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Publication details

The article was received on 13 Oct 2017, accepted on 28 Nov 2017 and first published on 28 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07932J
Citation: Chem. Commun., 2018, Advance Article
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    Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release

    X. Zhou, H. Li, M. He, X. Yin, D. Yao, S. Xiao and H. Liang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07932J

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