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A domain-based DNA circuit for smart single-nucleotide variant identification

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Abstract

According to the differential information of four homologous oligonucleotides, two domain-based encoders have been constructed with the molecular information as the input. Based on the one-to-one correspondence between the input and output, SNVs can be identified and their sites can be located at the domain level.

Graphical abstract: A domain-based DNA circuit for smart single-nucleotide variant identification

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Publication details

The article was received on 05 Oct 2017, accepted on 17 Nov 2017 and first published on 17 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07733E
Citation: Chem. Commun., 2018, Advance Article
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    A domain-based DNA circuit for smart single-nucleotide variant identification

    W. Zhong, W. Tang, J. Fan, J. Zhang, X. Zhou and Y. Liu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07733E

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