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Issue 7, 2018
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Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

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Abstract

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(IV) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

Graphical abstract: Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon

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Publication details

The article was received on 30 Sep 2017, accepted on 14 Dec 2017 and first published on 18 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC07622C
Citation: Chem. Commun., 2018,54, 731-734
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    Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

    Z. Yue, H. Wang, Y. Li, Y. Qin, L. Xu, D. J. Bowers, M. Gangoda, X. Li, H. Yang and Y. Zheng, Chem. Commun., 2018, 54, 731
    DOI: 10.1039/C7CC07622C

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