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Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

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Abstract

The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells and immune cells alike; however, no small molecule probes currently exist to selectively image Mer. In this work, we design and synthesize a selective near-infrared fluorescent molecular probe of Mer (MERi-SiR). Confocal microscopy of metastases in mice reveals predominant probe accumulation in Mer-expressing tumor-associated macrophages.

Graphical abstract: Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

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Publication details

The article was received on 28 Sep 2017, accepted on 23 Nov 2017 and first published on 23 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07581B
Citation: Chem. Commun., 2018, Advance Article
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    Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

    M. A. Miller, E. Kim, M. F. Cuccarese, A. L. Plotkin, M. Prytyskach, R. H. Kohler, M. J. Pittet and R. Weissleder, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07581B

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