Issue 10, 2018

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

Abstract

Polyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallodrugs. In this article, we focus on the antibacterial activity of POMs and their therapeutic potential in the battle against bacteria and their increasing resistance against pharmaceuticals. Recent advances in the synthesis of POMs are highlighted, with emphasis on the development and properties of biologically active POM-based hybrid and nanocomposite structures. By analysing the antibacterial activity and structure of POMs, putative mode of actions are provided, including potential targets for POM–protein interactions, and a structure–activity-relationship was established for a series of POMs against two bacteria, namely Helicobacter pylori and Streptococcus pneumoniae.

Graphical abstract: The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

Supplementary files

Article information

Article type
Feature Article
Submitted
27 Sep 2017
Accepted
02 Jan 2018
First published
12 Jan 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 1153-1169

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

A. Bijelic, M. Aureliano and A. Rompel, Chem. Commun., 2018, 54, 1153 DOI: 10.1039/C7CC07549A

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