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Issue 10, 2018
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An elimination/Heck coupling/allylation cascade reaction: synthesis of 2,3-dihydrobenzofurans from allenoate adducts

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Abstract

A highly regio- and stereoselective Pd-catalyzed cascade reaction of allenoate adducts has been developed. Various allenoate adducts of phosphine-catalyzed addition of allenoates are found to be efficient substrates for the preparation of 2,3-dihydrobenzofuran. It is the first example of allenoate adducts used as ideal and practical precursors of hard-to-get functionalized 1,3-butadienes for heterocycle synthesis.

Graphical abstract: An elimination/Heck coupling/allylation cascade reaction: synthesis of 2,3-dihydrobenzofurans from allenoate adducts

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Publication details

The article was received on 23 Sep 2017, accepted on 22 Dec 2017 and first published on 04 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC07435B
Citation: Chem. Commun., 2018,54, 1213-1216
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    An elimination/Heck coupling/allylation cascade reaction: synthesis of 2,3-dihydrobenzofurans from allenoate adducts

    J. Yang, H. Mo, H. Wu, D. Cao, C. Pan and Z. Wang, Chem. Commun., 2018, 54, 1213
    DOI: 10.1039/C7CC07435B

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