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Cu/Pd cooperatively catalyzed tandem intramolecular anti-Markovnikov hydroarylation of unsaturated amides: facile construction of 3,4-dihydroquinolinones via borylation/intramolecular C(sp3)–C(sp2) cross coupling

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Abstract

An anti-Markovnikov hydroarylation of unsaturated amides via a Cu/Pd synergistically catalyzed cascade borylation/intramolecular sp2–sp3 cross-coupling has been disclosed. 3,4-Dihydroquinolinones, one type of important scaffold prevailing in pharmaceuticals and biologically active compounds, could be readily accessible with high regio-selectivity and high yields.

Graphical abstract: Cu/Pd cooperatively catalyzed tandem intramolecular anti-Markovnikov hydroarylation of unsaturated amides: facile construction of 3,4-dihydroquinolinones via borylation/intramolecular C(sp3)–C(sp2) cross coupling

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Publication details

The article was received on 13 Sep 2017, accepted on 22 Nov 2017 and first published on 23 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07180A
Citation: Chem. Commun., 2018, Advance Article
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    Cu/Pd cooperatively catalyzed tandem intramolecular anti-Markovnikov hydroarylation of unsaturated amides: facile construction of 3,4-dihydroquinolinones via borylation/intramolecular C(sp3)–C(sp2) cross coupling

    Z. Kuang, B. Li and Q. Song, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07180A

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