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In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis

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Abstract

Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.

Graphical abstract: In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis

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Publication details

The article was received on 11 Sep 2017, accepted on 21 Nov 2017 and first published on 30 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07079A
Citation: Chem. Commun., 2018, Advance Article
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    In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis

    P. A. Storm and C. A. Townsend, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07079A

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