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Porous dipeptide crystals as volatile-drug vessels

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Abstract

Porous crystalline dipeptides absorb, reversibly from the gas phase, a series of volatile fluorinated ethers in use as anesthetics. Their vapor pressure was considerably reduced, with favorable guest capture and release. Variable channel sizes were customized for selective sorption and pressure thresholds were observed in the narrowest pores. 1H, 13C and 19F MAS NMR coupled with ab initio conformational analysis and grand canonical Monte Carlo simulations highlight the guest loading and arrangement adopted in the congruent nanochannels, suggesting how the anesthetics can accommodate in biochemical receptors.

Graphical abstract: Porous dipeptide crystals as volatile-drug vessels

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Publication details

The article was received on 19 Aug 2017, accepted on 25 Oct 2017 and first published on 06 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC06534E
Citation: Chem. Commun., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    Porous dipeptide crystals as volatile-drug vessels

    S. Bracco, D. Asnaghi, M. Negroni, P. Sozzani and A. Comotti, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC06534E

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