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Enzymatically cleavable traceless biotin tag for protein PEGylation and purification

Abstract

Here we report an example of protein–PEG conjugate with a biotin tag cleavable by lipase-catalyzed hydrolysis. Very mild cleavage conditions, heterogeneous, easily separable catalyst, and traceless design make this method attractive for preparation and purification of PEGylated proteins.

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Publication details

The article was received on 26 Jul 2017, accepted on 05 Jan 2018 and first published on 08 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC05814D
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Enzymatically cleavable traceless biotin tag for protein PEGylation and purification

    A. M. Wawro, Y. Aoki, T. Muraoka, K. Tsumoto and K. Kinbara, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC05814D

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