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The effects of Sr-incorporated micro/nano rough titanium surface on rBMSCs migration and osteogenic differentiation for rapid osteointegration

Abstract

Endogenous bone marrow-derived mesenchymal stem cells (BMSCs) recruitment has been widely discussed as an alternative strategy for bone regeneration. Strontium (Sr) is known to direct the BMSCs commitment to the bone lineage and encourage bone formation; however, the underlying mechanisms remain elusive. In this study, Sr-incorporated micro/nano rough titanium surface (MNT-Sr) was fabricated by hydrothermal treatment, in an attempt to facilitate BMSCs recruitment and osteogenic differentiation to enhance rapid osseointegration. Micro rough titanium (MT) was set as the control biomaterial. In vitro, the MNT-Sr and its extracts promoted the migration and osteogenic differentiation of BMSCs. In animal studies, green fluorescent protein (GFP)-labeled BMSCs were intravenously injected into wild-type rats for tracing before tibial implantation surgery. GFP+BMSCs recruitment to the implantation site was successfully triggered by MNT-Sr implantation. A trend for increased bone area (BA%), bone-implant contact (BIC%) and removal torque values (RTVs) were observed for MNT-Sr implant compared to MT at 2 weeks. Advanced mechanism analysis indicated that Sr2+ enhanced the SDF-1α/CXCR4 signaling pathway both in vitro and in vivo. Taken together, these findings suggest that the MNT-Sr has a promising therapeutic potential for future use in dental implants by homing endogenous cells to stimulate bone regeneration.

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Publication details

The article was accepted on 10 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8BM00473K
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    The effects of Sr-incorporated micro/nano rough titanium surface on rBMSCs migration and osteogenic differentiation for rapid osteointegration

    C. Zhou, A. Xu, D. Wang, G. Lin, T. Liu and F. He, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00473K

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