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Mechanistic Insight into the Singlet Oxygen-Triggered Expansion of Hypoxia-Responsive Polymeric Micelles

Abstract

Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way of developing dually hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on simple nitroimidazole moiety.

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Publication details

The article was received on 29 Mar 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Communication
DOI: 10.1039/C8BM00369F
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Mechanistic Insight into the Singlet Oxygen-Triggered Expansion of Hypoxia-Responsive Polymeric Micelles

    L. Wang, X. Huang, B. Wang, J. Zhao, X. Guo, Z. Wang and Y. Zhao, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00369F

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