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Highly reactive crystalline phase embedded strontium-bioactive nanorods for multimodal bioactive applications.

Abstract

In the present work, crystallization induced strontium-Bioactive material, a composition similar to Bioglass 45S5 system have been obtained by sol-gel assisted microwave method with the nanorod morphologies of size varying from 30 nm to 80 nm. The effect of crystallization induced in the glass network and its influence on bioactivity and mechanical properties of bone and dentin regeneration is the prime novelty of the present work. Rietveld analysis of X-ray diffraction spectra shows the best fit with sodium (combeite -Na2Ca2Si3O9) and calcium (clinoposinate - Ca2Na6O14P2Si2, calcium strontium silicate - Ca1.5O4SiSr0.5 and calcium carbonate -CaCO3) enriched crystal systems. Multinuclear solid state NMR studies provide detailed atomistic insights on the presence of crystalline mineral phases in the Bioactive material. The dentin matrix and the antibacterial studies were found to be high for 5% strontium substituted calcium from the basic 45S5 composition due to its smaller particle size 30 nm and suggested for dentin regeneration applicability. The simulation studies have been demonstrated with clinoposinate crystal data from the XRD spectra with the glycoprotein salivary metabolites also shows that 5% strontium substituted calcium has higher binding affinity to the salivary compound which is suitable for dentin regeneration application. The in vitro apatite formation studies shows that this material is suitable for bone regeneration applications.

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Publication details

The article was received on 28 Mar 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Paper
DOI: 10.1039/C8BM00362A
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Highly reactive crystalline phase embedded strontium-bioactive nanorods for multimodal bioactive applications.

    D. Durgalakshmi, A. R. Rajendran, K. Muthu, S. Ganapathy, T. G. Ajithkumar, S. Karthikeyan and B. Subramanian, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00362A

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