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Ag/AgBr Loaded Mesoporous Silica for Rapid Sterilization and Promotion of Wound Healing

Abstract

Bacterial infection is a major concern during wound healing. Herein, Ag/AgBr loaded mesoporous silica nanoparticles (Ag/AgBr/MSNs) are designed and prepared to harvest visible light for rapid sterilization and accelerated wound healing. The Ag/AgBr nanostructure has excellent photocatalytic ability and electron−hole pairs generated by light absorption enhance the antibacterial properties by producing reactive oxygen species (ROS). The bacteria killing effeciency of Ag/AgBr/MSNs is 95.62% and 99.99% against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), respectively, after simulated solar light irradiation for only 15 minutes. The composite arrests bacteria and damages the bacterial membranes via electrostatic interaction. Furthermore, Ag+ ions released gradually from the materials prevent bacterial infection for a long period of time and simultaneously stimulate immune functions to produce a large number of white blood cells and neutrophils to promote wound healing.

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Publication details

The article was received on 25 Mar 2018, accepted on 09 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8BM00353J
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Ag/AgBr Loaded Mesoporous Silica for Rapid Sterilization and Promotion of Wound Healing

    C. Jin, X. Liu, L. Tan, Z. Cui, X. Yang, Y. Zheng, K. Yeung, P. K. Chu and S. Wu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00353J

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