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Layered double hydroxide/poly-dopamine composite coating with surface heparinization on Mg alloy: improved anticorrosion, endothelialization and hemocompatibility

Abstract

Magnesium (Mg) and its alloys are promising cardiovascular stents materials for its favourable physical properties and complete degradation in vivo. However, rapid degradation and poor cytocompatibility hinder their clinical applications. To enhance the corrosion resistance and endothelialization of AZ31 alloy, a layered double hydroxide (LDH) / poly-dopamine (PDA) composite coating (LDH/PDA) was successfully fabricated. Polarization curves and electrochemical impedance spectroscopy Nyquist spectrum test proved that the corrosion resistance of LDH/PDA sample was significantly improved in vitro. LDH/PDA sample greatly improved the adherence process and proliferation rate of human umbilical vein endothelial cells (HUVECs). After culturing for 10 days, the number of living HUVECs on LDH/PDA sample was comparable to that on Ti sample whereas the cells barely survived on AZ31 or LDH coating. Furthermore, heparin was immobilized on LDH/PDA via the covalent bond (LDH/PDA/HEP). The corrosion resistance and long-term proliferation of HUVECs after introduction of heparin were mildly decreased compared with L/P sample, but were still greatly improved compared with AZ31, LDH coating and PDA coating. Furthermore, the LDH/PDA/HEP sample greatly improved the HUVECs migration rate compared with LDH/PDA sample, and inhibited platelets adhesion which was intense on LDH/PDA sample. Both LDH/PDA and LDH/PDA/HEP samples had low hemolysis rate (2.52% and 0.65%, respectively) in vitro and eliminated the adverse biocompatible effects of the direct PDA coating on AZ31 substrate in vivo. Our results suggest that the LDH/PDA composite coating with further heparinization is a promising method to modify the surface of Mg alloys by significantly improving corrosion resistance, endothelialization and hemocompatibility.

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Publication details

The article was received on 13 Mar 2018, accepted on 25 Apr 2018 and first published on 27 Apr 2018


Article type: Paper
DOI: 10.1039/C8BM00298C
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Layered double hydroxide/poly-dopamine composite coating with surface heparinization on Mg alloy: improved anticorrosion, endothelialization and hemocompatibility

    H. Li, F. Peng, D. Wang, Y. Qiao, D. Xu and X. Liu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00298C

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