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Injectable shear thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors


Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We used a silicate-based shear-thinning hydrogel (STH) to engineer an injectable scaffold and incorporated polycaprolactone (PCL) nanoparticles that entrap and release vasculogenic growth factors in a controlled manner. By adjusting the solid composition of gelatin and silicate nanoplatelets in the STH, we defined optimal conditions that enable injection of STHs, which can deliver cells and growth factors. Different types of STHs could be simultaneously injected into 3D constructs through a single head composed of multiple syringes and needles, while maintaining its engineered structure in a continuous manner. Injected STHs were also capable of filling any irregularly shaped defects in bone. Osteogenic cells and endothelial cells were encapsulated in STHs with and without vasculogenic growth factors respectively, and when co-cultured, their growth and differentiation were significantly enhanced compared to cells grown in monoculture. This study introduces an initial step of developing a new platform of shape tunable material with a controlled release of angiogenic growth factors by utilizing PCL nanoparticles.

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Publication details

The article was received on 12 Mar 2018, accepted on 12 Apr 2018 and first published on 17 Apr 2018

Article type: Paper
DOI: 10.1039/C8BM00293B
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Injectable shear thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors

    E. Alarcin, T. Y. Lee, S. Karuthedom, M. Mohammadi, M. A. Brennan, D. H. Lee, A. Marrella, J. Zhang, D. Syla, Y. S. Zhang, A. Khademhosseini and H. L. Jang, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00293B

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