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Targeted delivery of tungsten oxide nanoparticles for multifunctional anti-tumor therapy via macrophages

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Abstract

Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines. Meanwhile, to improve the tumor-killing effect and track the collaborative therapy system in vivo, a novel nanoplatform based on tungsten oxide (W18O49, WO) nanoparticles and fluorescent dyes loaded in polylactic-co-glycolic acid (PLGA) for PTT has been successfully constructed. Subsequently, the nanoparticles are swallowed by macrophages acting as cell-based biocarriers to target the tumor and promote solid tumor ablation in vivo in animal experiments. This system is expected to bring a huge application potential in the visually guided dual-modal therapeutic platform for tumor targeting therapy in vivo.

Graphical abstract: Targeted delivery of tungsten oxide nanoparticles for multifunctional anti-tumor therapy via macrophages

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Publication details

The article was received on 22 Feb 2018, accepted on 26 Mar 2018 and first published on 29 Mar 2018


Article type: Paper
DOI: 10.1039/C8BM00218E
Citation: Biomater. Sci., 2018, Advance Article
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    Targeted delivery of tungsten oxide nanoparticles for multifunctional anti-tumor therapy via macrophages

    B. Zheng, Y. Bai, H. Chen, H. Pan, W. Ji, X. Gong, X. Wu, H. Wang and J. Chang, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM00218E

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