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Co-delivery of timolol and hyaluronic acid from semi-circular rings implanted contact lenses for the treatment of glaucoma: In vitro and in vivo evaluation

Abstract

Glaucoma is a chronic disease which is currently treated using high dose frequent application of eye drop solutions, this method is tedious and patient noncompliant. Contact lenses are emerging as convenient option to sustain the release of ophthalmic drugs. But incorporation of drug/formulation changes the optical and physical properties of the contact lenses. Contact lens users have also reported pink eye syndrome, making it unsuitable to be accepted as medical device. The objective of the present work was to design a novel timolol and hyaluronic acid (comfort agent) loaded semi-circular rings implanted contact lenses that could uphold the release at therapeutic rates without compromising critical lens properties. The drug loaded rings were implanted separately within the periphery of the contact lenses using modified cast moulding technology. The atomic force microscopy report showed an average roughness of 12.38 nm for implanted lens, which was significantly lower in comparison to Freshlook contact lens (116.27 nm). The major amount of timolol was leached (46.47 to 58.79%) during the monomer extraction and moist sterilization (autoclave) steps; therefore the lenses were sterilized by radiation and packaged under dry condition (dehydrated). The in vitro release data showed sustained release for timolol and hyaluronic acid up to 96 h. The in vivo drug release study on rabbit eyes showed the presence of timolol in tear fluid up to 72 h. The in vivo pharmacodynamics studies showed reduction in IOP till 144 h with low drug loading (154 µg) in comparison to single instillation eye drop solution (250 µg). The study demonstrated the successful application of implantation technology to co-deliver timolol and hyaluronic acid from the contact lenses for extended period of time to treat glaucoma.

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Publication details

The article was received on 21 Feb 2018, accepted on 13 Apr 2018 and first published on 16 Apr 2018


Article type: Paper
DOI: 10.1039/C8BM00212F
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Co-delivery of timolol and hyaluronic acid from semi-circular rings implanted contact lenses for the treatment of glaucoma: In vitro and in vivo evaluation

    A. Desai, F. A. Maulvi, M. Pandya, K. Ranch , B. Vyas, S. Shah and D. O. Shah, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00212F

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