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Issue 5, 2018
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Chitosan-catechol: a writable bioink under serum culture media

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Abstract

Mussel-inspired adhesive coatings on biomedical devices have attracted significant interest due to their unique properties such as substrate independency and high efficiency. The key molecules for mussel-inspired adhesive coatings are catechol and amine groups. Along with the understanding of catechol chemistry, chitosan-catechol has also been developed as a representative mussel-inpired adhesive polymer that contains catechol and amine groups for adhesiveness. Herein, we demonstrated the direct writability of chitosan-catechol as a bioink for 3D printing, one of the additive techniques. The use of chitosan-catechol bioink results in the formation of 3D constructs in normal culture media via rapid complexation of this bioink with serum proteins; in addition, the metal/catechol combination containing tiny amounts of vanadyl ions, in which the ratio of metal to catechol is 0.0005, dramatically enhances the mechanical strength and printability of the cell-encapsulated inks, showing a cell viability of approximately 90%. These findings for mussel-inspired bioinks will be a promising way to design a biocompatible 3D bioink cross-linked without any external stimuli.

Graphical abstract: Chitosan-catechol: a writable bioink under serum culture media

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Publication details

The article was received on 12 Feb 2018, accepted on 27 Mar 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8BM00174J
Citation: Biomater. Sci., 2018,6, 1040-1047
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    Chitosan-catechol: a writable bioink under serum culture media

    D. Lee, J. P. Park, M. Koh, P. Kim, J. Lee, M. Shin and H. Lee, Biomater. Sci., 2018, 6, 1040
    DOI: 10.1039/C8BM00174J

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