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Microgel Core/Shell Architectures as Targeted Agents for Fibrinolysis

Abstract

We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide-microgel hybrids in clot disruption and clotting modulation.

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Publication details

The article was received on 29 Jan 2018, accepted on 13 Jun 2018 and first published on 14 Jun 2018


Article type: Communication
DOI: 10.1039/C8BM00119G
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Microgel Core/Shell Architectures as Targeted Agents for Fibrinolysis

    P. Kodlekere and A. Lyon, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00119G

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