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Issue 5, 2018
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Regulating the local pH level of titanium via Mg–Fe layered double hydroxides films for enhanced osteogenesis

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Abstract

Hard tissue implant materials which can cause a suitable alkaline microenvironment are thought to be beneficial for stimulating osteoblast differentiation while suppressing osteoclast generation. To make the local pH around the interface between materials and cells controllable, we prepared a series of Mg–Fe layered double hydroxide (LDH) films on acid-etched pure titanium surfaces via hydrothermal treatment. By adjusting the Mg/Fe proportion ratio, the interlayer spacing of Mg–Fe LDHs was regulated, making their OH exchange abilities adjustable, and this ultimately resulted in a microenvironment with a controllable pH value. In vitro experiments demonstrated that the Mg–Fe LDH film-modified titanium surface possessed good biocompatibility and osteogenic activity, especially the Mg–Fe LDH film with Mg/Fe proportion ratio of 4, which could form a suitable alkaline microenvironment for the growth and osteogenetic differentiation of stem cells. These results demonstrate the potential application of the prepared Mg–Fe LDH films in enhancing the osteogenesis of implant materials while providing a new way into the design of controllable alkaline environment.

Graphical abstract: Regulating the local pH level of titanium via Mg–Fe layered double hydroxides films for enhanced osteogenesis

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Publication details

The article was received on 26 Jan 2018, accepted on 12 Mar 2018 and first published on 13 Mar 2018


Article type: Paper
DOI: 10.1039/C8BM00100F
Citation: Biomater. Sci., 2018,6, 1227-1237
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    Regulating the local pH level of titanium via Mg–Fe layered double hydroxides films for enhanced osteogenesis

    Q. Li, D. Wang, J. Qiu, F. Peng and X. Liu, Biomater. Sci., 2018, 6, 1227
    DOI: 10.1039/C8BM00100F

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