Jump to main content
Jump to site search


Synergistic effects of hyaluronate – epidermal growth factor conjugate patch on chronic wound healing

Author affiliations

Abstract

The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA–EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF. According to ELISA, the HA–EGF conjugates showed a long-term stability compared with native EGF. Furthermore, HA–EGF conjugates appeared to interact with skin cells through two types of HA and EGF receptors, resulting in a synergistically improved healing effect. Taken together, we could confirm the feasibility of HA–EGF conjugates for the transdermal treatment of chronic wounds.

Graphical abstract: Synergistic effects of hyaluronate – epidermal growth factor conjugate patch on chronic wound healing

Back to tab navigation

Publication details

The article was received on 22 Jan 2018, accepted on 11 Mar 2018 and first published on 14 Mar 2018


Article type: Paper
DOI: 10.1039/C8BM00079D
Citation: Biomater. Sci., 2018, Advance Article
  •   Request permissions

    Synergistic effects of hyaluronate – epidermal growth factor conjugate patch on chronic wound healing

    Y. S. Kim, D. K. Sung, W. H. Kong, H. Kim and S. K. Hahn, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM00079D

Search articles by author

Spotlight

Advertisements