Horseradish peroxidase-catalyzed hydrogelation for biomedical applications
Abstract
Hydrogels catalyzed by horseradish peroxidase (HRP) serve as an efficient and effective platform for biomedical applications due to its mild reaction condition for cells, fast and adjustable gelation rate in physiological condition and the abundance of substrates as water-soluble biocompatible polymers. In this review, we highlight the tunable characteristics and use of the HRP catalyzed hydrogels and provide a brief overview of various substrates employed in the HRP system for different biomedical applications of the resultant hydrogels. In addition, we discuss and summarize the biocompatibility, possible functionalization, and biofabrication process. Finally, the future prospective of HRP crosslinking system is highlighted in biomedical applications.