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Horseradish peroxidase-catalyzed hydrogelation for biomedical applications

Mehdi Khanmohammadi,  Mahsa Borzouyan Dastgerdi,  Arman Ai,  Akbar Ahmadi,  Arash Goodarzi,  Azam Rahimi  and  Jafar Ai 

Abstract

Hydrogels catalyzed by horseradish peroxidase (HRP) serve as an efficient and effective platform for biomedical applications due to its mild reaction condition for cells, fast and adjustable gelation rate in physiological condition and the abundance of substrates as water-soluble biocompatible polymers. In this review, we highlight the tunable characteristics and use of the HRP catalyzed hydrogels and provide a brief overview of various substrates employed in the HRP system for different biomedical applications of the resultant hydrogels. In addition, we discuss and summarize the biocompatibility, possible functionalization, and biofabrication process. Finally, the future prospective of HRP crosslinking system is highlighted in biomedical applications.

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Publication details

The article was received on 15 Jan 2018, accepted on 13 Apr 2018 and first published on 17 Apr 2018


Article type: Review Article
DOI: 10.1039/C8BM00056E
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Horseradish peroxidase-catalyzed hydrogelation for biomedical applications

    M. Khanmohammadi, M. B. Dastgerdi, A. Ai, A. Ahmadi, A. Goodarzi, A. Rahimi and J. Ai, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00056E

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