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Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

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Abstract

Temperature-responsive cell culture substrates reported here can be dynamically programmed to induce bulk softening and surface roughness changes in the presence of living cells. Alterations in hepatocellular function following temporally controlled substrate softening depend on the extent of stiff mechanical priming prior to user-induced material transition.

Graphical abstract: Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

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Publication details

The article was received on 13 Jan 2018, accepted on 06 Mar 2018 and first published on 09 Mar 2018


Article type: Communication
DOI: 10.1039/C8BM00047F
Citation: Biomater. Sci., 2018, Advance Article
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    Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

    K. Uto, T. Aoyagi, C. A. DeForest and M. Ebara, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM00047F

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