Jump to main content
Jump to site search


Eumelanin–Fe3O4 hybrid nanoparticles for enhanced MR/PA imaging-assisted local photothermolysis

Author affiliations

Abstract

In this work, we report on biodegradable eumelanin–Fe3O4 hybrid nanoparticles (euMel–Fe3O4 NPs) for multiple imaging-assisted local photothermolysis. The euMel–Fe3O4 NPs are rationally prepared via a facile one-step co-precipitation method in the aqueous phase in the presence of eumelanin. The obtained NPs exhibited high stability and aqueous dispersity. euMel–Fe3O4 NPs could provide T2-weighted magnetic resonance (MR) and photoacoustic (PA) imaging contrast enhancement prior to the treatment, due to their high r2 relaxivity that was determined to be 245.88 mM−1 s−1 (a value higher than those for other commercially available iron oxide NPs) and good PA signal intensity. Besides, with effective NIR absorbance, the euMel–Fe3O4 NPs promoted an effective photothermolysis treatment in an experimental mouse model of cancer. Cytotoxicity and in vivo histological examination demonstrated no appreciable toxicity. Our work suggests that euMel–Fe3O4 NPs could be proposed as a potential class of theranostic nanoplatform with multiple imaging modalities for cancer therapy.

Graphical abstract: Eumelanin–Fe3O4 hybrid nanoparticles for enhanced MR/PA imaging-assisted local photothermolysis

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Jan 2018, accepted on 16 Jan 2018 and first published on 17 Jan 2018


Article type: Paper
DOI: 10.1039/C8BM00003D
Citation: Biomater. Sci., 2018, Advance Article
  •   Request permissions

    Eumelanin–Fe3O4 hybrid nanoparticles for enhanced MR/PA imaging-assisted local photothermolysis

    J. Wang, H. Liu, Y. Liu, C. Chu, Y. Yang, Y. Zeng, W. Zhang and G. Liu, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM00003D

Search articles by author

Spotlight

Advertisements