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Recent Progress on the Development of Near-infrared Organic Photothermal and Photodynamic Nanotherapeutics

Abstract

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to its high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue. In contrast to inorganic nanoparticles, near-infrared (NIR) absorbing organic nanoparticles bypass the issue of metal-ion induced toxicity and thus are generally considered to be more biocompatible. With the guidance of different kinds of imaging methods, the efficacy of organic nanoparticle based cancer phototherapy has shown to be optimizable. In this review, we summarize the synthesis and application of NIR-absorbing organic nanoparticles as phototherapeutic nanoagents for cancer therapy. The chemistry, optical proprieties and therapeutic efficacies of organic nanoparticles are first described. Their phototherapy applications are then surveyed in terms of therapeutic modalities, which include PTT, PDT and PTT/PDT combined therapy. At last, the present challenges and potentials of imaging guided PTT/PDT are discussed.

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Publication details

The article was received on 29 Dec 2017, accepted on 05 Feb 2018 and first published on 06 Feb 2018


Article type: Review Article
DOI: 10.1039/C7BM01210A
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Recent Progress on the Development of Near-infrared Organic Photothermal and Photodynamic Nanotherapeutics

    H. Zhu, P. Cheng, P. Chen and K. Pu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01210A

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