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Issue 5, 2018
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A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance

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Abstract

The integration of various therapy strategies into a single nanoplatform for synergistic cancer treatment has presented a great prospect. Herein, docetaxel (DTX)-loaded poly lactic-co-glycolic acid (PLGA)-coated polydopamine modified with D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) was synthesized for chemo-photothermal synergistic therapy against cancer. Firstly, the DTX-loaded PLGA NPs were prepared by a facile and robust nanoprecipitation method. Then, they were coated with dopamine to achieve the photothermal effects and to be further modified with TPGS, which can inhibit the P-glycoprotein-mediated multidrug resistance (MDR). The near-infrared (NIR) laser irradiation triggered DTX release from DTX-loaded PLGA NPs@PDA-TPGS, and then the chemo-photothermal therapy effect could be enhanced. The in vitro experimental results illustrated that DTX-loaded PLGA NPs@PDA-TPGS exhibits excellent photothermal conservation properties and remarkable cell-killing efficiency. In vivo antitumor studies further confirmed that DTX-loaded PLGA NPs@PDA-TPGS could present an outstanding synergistic antitumor efficacy compared with any monotherapy. This work exhibits a novel nanoplatform, which could not only load chemotherapy drugs efficiently, but could also improve the therapeutic effect of chemotherapy drugs by overcoming MDR and light-mediated photothermal cancer therapy.

Graphical abstract: A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance

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Publication details

The article was received on 27 Dec 2017, accepted on 19 Feb 2018 and first published on 20 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01206C
Citation: Biomater. Sci., 2018,6, 1084-1098
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    A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance

    Y. Peng, J. Nie, W. Cheng, G. Liu, D. Zhu, L. Zhang, C. Liang, L. Mei, L. Huang and X. Zeng, Biomater. Sci., 2018, 6, 1084
    DOI: 10.1039/C7BM01206C

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