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Self-Aggregation of Water-Dispersible Nanocollagen Helices

Abstract

Inspired by nature, collagen is an outstanding polypeptide being utilized to exploit their bioactivities and material design for healthcare technologies. In this work, we describe the self-aggregation of water-dispersible nanocollagen helices on solidification to fabricate different forms of natural collagen materials. Chemically extracted native collagen fibrils are uniform anisotropic nanoparticles with an average diameter of about 50 nm and having a high aspect ratio. The as-prepared collagen nanofibrils are soluble in sodium acetic-acetic acid buffer and are dispersible in water to generate collagen liquids that are used as distinct biopolymer precursors for material development. Our interesting finding shows that water-dispersible collagen-derived alcogels underwent critical point drying to self-arrange hierarchical nanofibrils into helix bundles in collagen sponge-like aerogels. By using the lyophilization to remove water in the biopolymer dispersion, it is worthy to achieve a full regeneration of solidified fibers, producing collagen aerogels with lightweight characteristics like natural cottons. The self-aggregation of water-dispersible collagen occurs under freeze-drying conditions to turn individual nanofibrils into sheets with layered structures in the aerogel networks. The design of transparent, water resistant collagen bioplastic-like membranes was explored from the supramolecular self-assembly of water-dispersible collagen nanofibrils. Our efforts present a reliable concept in soft matter for creating promising collagen examples of liquids, hydrogels, aerogels, and membranes to increase utilization values of native collagen for biomedicine, pharmaceuticals, cosmetics, and nutrients.

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Publication details

The article was received on 07 Dec 2017, accepted on 09 Feb 2018 and first published on 09 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01141E
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Self-Aggregation of Water-Dispersible Nanocollagen Helices

    T. Nguyen, H. V. Duong, T. T.L. Chau, N. T. Dang, D. V. Nguyen, S. L. Le, T. S. Ho, T. P. Vu and T. V.T. Tran, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01141E

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