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Issue 4, 2018
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Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

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Abstract

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4:Er3+,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as therapy agents by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency. This work highlights the potential of UCNP@NGO nanocomposites as an integrated theranostic nanoplatform for the UCL image combinatorial PTT of cancer, providing a promising candidate for clinical antitumor treatments.

Graphical abstract: Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

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Publication details

The article was received on 30 Nov 2017, accepted on 26 Jan 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01113J
Citation: Biomater. Sci., 2018,6, 877-884
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    Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

    P. Li, Y. Yan, B. Chen, P. Zhang, S. Wang, J. Zhou, H. Fan, Y. Wang and X. Huang, Biomater. Sci., 2018, 6, 877
    DOI: 10.1039/C7BM01113J

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