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Lanthanide-doped upconversion nanoparticles complexed with nano oxide graphene used for upconversion fluorescence imaging and photothermal therapy

Abstract

In recent years, multifunctional nanoparticles have attracted lots of research interests in various biomedical applications such as biosensors, diagnosis, and drug delivery system. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4:Er3+,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as a therapy agent by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency. This work highlights the potentials of UCNP@NGO nanocomposites as an integrated theranostic nanoplatform for UCL image combinatorial PTT of cancer, providing a promising candidate for clinical antitumor treatments.

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Publication details

The article was received on 30 Nov 2017, accepted on 26 Jan 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01113J
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Lanthanide-doped upconversion nanoparticles complexed with nano oxide graphene used for upconversion fluorescence imaging and photothermal therapy

    P. Li, Y. Yan, B. Chen, P. Zhang, S. Wang, J. Zhou, H. Fan, Y. Wang and X. Huang, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01113J

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