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Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

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Abstract

Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy.

Graphical abstract: Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

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Publication details

The article was received on 22 Nov 2017, accepted on 30 Jan 2018 and first published on 02 Feb 2018


Article type: Communication
DOI: 10.1039/C7BM01082F
Citation: Biomater. Sci., 2018, Advance Article
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    Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

    F. Q. Cao, M. M. Yan, Y. J. Liu, L. X. Liu, L. Lu, H. Wang, Ch. Zhang, H. F. Sun, D. L. Kong and G. L. Ma, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C7BM01082F

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