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Mussel-inspired graphene oxide nanosheets enwrapped Ti scaffolds with drugs encapsulated gelatin microspheres for bone regeneration

Abstract

Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have good biocompatibility and wide applications in bone engineering. In this study, a GO-functionalized Ti porous scaffold (GO/Ti scaffold) was prepared by depositing GO onto polydopamine (PDA) modified Ti scaffolds. The mussel inspired PDA modification facilitated the interaction between GO and Ti surfaces, leading to a uniform coverage of GO on Ti scaffolds. BMP2 and vancomycin (Van) were separately encapsulated into gelatin microspheres (GelMS). Then drug-contained GelMS were assembled on GO/Ti scaffolds and anchored by the functional groups of GO. The modified scaffold independently delivered multiple biomolecules with different physiochemical properties, without interfering with each other. Thus, the GO/Ti scaffold with the dual functions of inducing bone regeneration and preventing bacterial infection. In summary, this mussel-inspired GO/Ti hybrid scaffold combined the good mechanical properties of Ti scaffolds and the advantages of GO nanosheets. GO nanosheets with their unique nanostructure and functional groups, together with GelMS on Ti scaffolds, are suitable carriers for drug delivery and provide adhesive sites for cell adhesion and create nanostructured environments for bone regeneration.

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Publication details

The article was received on 16 Nov 2017, accepted on 10 Jan 2018 and first published on 12 Jan 2018


Article type: Paper
DOI: 10.1039/C7BM01060E
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Mussel-inspired graphene oxide nanosheets enwrapped Ti scaffolds with drugs encapsulated gelatin microspheres for bone regeneration

    L. Han, H. Sun, P. Li, P. Tang, C. Xie, M. Wang, K. Wang, J. Weng, H. Tan, F. Ren and X. Lu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01060E

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