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Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

Abstract

The nonspecific biodistribution of cytotoxic drugs and associated adverse effects greatly limit the efficacy and patient compliance of chemotherapy. To address this, we employed a photoswitchable microtubule inhibitor (Azo-CA4) that was physically loaded in cyclodextrin-bearing micellar nanocarriers through the host-guest interaction. Azo-CA4 was only activated upon ultraviolet (UV) light irradiation to trigger the transition from “trans” (inactive) to “cis” (active) state. Such conformation change could then induce rapid Azo-CA4 release from micelles without the delay of onset of therapeutic action. This nanoscale delivery system produced photo-triggered antimitotic and pro-apoptotic effects in MDA-MB-231 cells via triggered control of microtubule dynamics. The anticancer efficacy of Azo-CA4-loaded micelles was further proved in vivo using a 4T1 tumor-bearing mice model coupled with multiple topical administrations to avoid the penetration problem of UV light. This work provides a new delivery vehicle to aid the application and potential translation of Azo-CA4 as biomedical tools and precision chemotherapeutics.

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Publication details

The article was received on 15 Nov 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Paper
DOI: 10.1039/C7BM01053B
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

    C. Chen, J. Zhao, M. Gao, X. Meng, A. Fan, Z. Wang and Y. Zhao, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01053B

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