Jump to main content
Jump to site search

Issue 3, 2018
Previous Article Next Article

Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

Author affiliations

Abstract

The nonspecific biodistribution of cytotoxic drugs and associated adverse effects greatly limit the efficacy and patient compliance of chemotherapy. To address this, we employed a photoswitchable microtubule inhibitor (Azo-CA4) that was physically loaded in cyclodextrin-bearing micellar nanocarriers through the host–guest interaction. Azo-CA4 was only activated upon ultraviolet (UV) light irradiation to trigger the transition from the “trans” (inactive) to “cis” (active) state. Such conformation change could then induce rapid Azo-CA4 release from micelles without the delay of the onset of therapeutic action. This nanoscale delivery system produced photo-triggered antimitotic and pro-apoptotic effects in MDA-MB-231 cells via a triggered control of microtubule dynamics. The anticancer efficacy of Azo-CA4-loaded micelles was further proved in vivo using a 4T1 tumor-bearing mice model coupled with multiple topical administrations to avoid the penetration problem of UV light. This work provides a new delivery vehicle to aid the application and potential translation of Azo-CA4 as biomedical tools and precision chemotherapeutics.

Graphical abstract: Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Nov 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Paper
DOI: 10.1039/C7BM01053B
Citation: Biomater. Sci., 2018,6, 511-518
  •   Request permissions

    Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

    C. Chen, J. Zhao, M. Gao, X. Meng, A. Fan, Z. Wang and Y. Zhao, Biomater. Sci., 2018, 6, 511
    DOI: 10.1039/C7BM01053B

Search articles by author

Spotlight

Advertisements