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Issue 3, 2018
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3D cellular structures and co-cultures formed through the contactless magnetic manipulation of cells on adherent surfaces

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Abstract

A magnet array is employed to manipulate diamagnetic cells that are contained in paramagnetic medium to demonstrate for the first time the contactless bioprinting of three-dimensional (3D) cellular structures and co-cultures of breast cancer MCF-7 and endothelial HUVEC at prescribed locations on tissue culture treated well plates. Sequential seeding of different cell lines and the spatial displacement of the magnet array creates co-cultured cellular structures within a well without using physically intrusive well inserts. Both monotypic and co-culture experiments produce morphologically rich 3D cell structures that are otherwise absent in regular monolayer cell cultures. The magnetic contactless bioprinting of cells provides further insight into cell behaviour, invasion strategies and transformations that are useful for potential applications in drug screening, 3D cell culture formation and tissue engineering.

Graphical abstract: 3D cellular structures and co-cultures formed through the contactless magnetic manipulation of cells on adherent surfaces

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Publication details

The article was received on 14 Nov 2017, accepted on 31 Jan 2018 and first published on 01 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01050H
Citation: Biomater. Sci., 2018,6, 683-694
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    3D cellular structures and co-cultures formed through the contactless magnetic manipulation of cells on adherent surfaces

    A. R. Abdel Fattah, S. Mishriki, T. Kammann, R. P. Sahu, F. Geng and I. K. Puri, Biomater. Sci., 2018, 6, 683
    DOI: 10.1039/C7BM01050H

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