Jump to main content
Jump to site search

Issue 4, 2018
Previous Article Next Article

Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications

Author affiliations

Abstract

Due to their intrinsic physical properties potentially useful for imaging and therapy as well as their highly engineerable surface, biocompatible inorganic nanoparticles offer novel platforms to develop advanced diagnostic and therapeutic agents for improved detection and more efficacious treatment of major diseases. The in vivo application of inorganic nanoparticles was demonstrated more than two decades ago, however it turns out to be very complicated as nanomaterials exhibit much more sophisticated pharmacokinetic properties than conventional drugs. In this review, we first discuss the in vivo behavior of inorganic nanoparticles after systematic administration, including the basic requirements for nanoparticles to be used in vivo, the impact of the particles’ physicochemical properties on their pharmacokinetics, and the effects of the protein corona formed across the nano–bio interface. Next, we summarize the state-of-the-art of the preparation of biocompatible inorganic nanoparticles and bioconjugation strategies for obtaining target-specific nanoprobes. Then, the advancements in sensitive tumor imaging towards diagnosis and visualization of the abnormal signatures in the tumor microenvironment, together with recent studies on atherosclerosis imaging are highlighted. Finally, the future challenges and the potential for inorganic nanoparticles to be translated into clinical applications are discussed.

Graphical abstract: Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications

Back to tab navigation

Publication details

The article was received on 09 Nov 2017, accepted on 14 Dec 2017 and first published on 14 Dec 2017


Article type: Review Article
DOI: 10.1039/C7BM01020F
Citation: Biomater. Sci., 2018,6, 726-745
  •   Request permissions

    Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications

    M. Jiao, P. Zhang, J. Meng, Y. Li, C. Liu, X. Luo and M. Gao, Biomater. Sci., 2018, 6, 726
    DOI: 10.1039/C7BM01020F

Search articles by author

Spotlight

Advertisements