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The effects of surface bioactivity and sustained-release of genistein from mesoporous magnesium-calcium-silicate/PK composite stimulating cells responses in vitro, and promoting osteogenesis and enhancing osseointegration in vivo

Abstract

The surface of mesoporous magnesium-calcium-silicate (m-MCS)/polyetheretherketone (PK) composite (MPC) were modified by sand blasting, and genistein (GS) was loaded inside the nanopores of m-MCS on the modified MPC (MPCm) surface. The results showed that compared with MPC, surface roughness and hydrophilcity of MPCm obviously improved with more m-MCS exposing on its surface. Moreover, no obvious differences in surface roughness and hydrophilcity were found between MPCm and GS loaded MPCm (MPCm-Ge), and both of them possessed improved apatite mineralization ability in simulated body fluid solution (SBF) compared with MPC, indicating excellent surface bioactivity. Moreover, the MPCm obviously stimulated the adhesion, proliferation and differentiation of MC3T3-E1 cells compared with MPC, and the sustained-release of GS from MPCm-Ge surface further significantly promoted the cells proliferation and differentiation. According to the Micro-CT, histological and SEM analysis, the results demonstrated that the MPCm obviously improved osteogenesis and enhanced osseointegration in vivo compared with MPC, and the release of GS from MPCm-Ge surface further significantly improved osteogenesis and enhanced osseointegration. In summary, the significant promotion of cells responses in vitro, and improvements of osteogenesis and enhancement of osseointegration in vivo were attributed to the synergistic effects of surface bioactivity and GS sustained-release from MPCm-Ge surface. Therefore, the MPCm-Ge would be a potential candidate for orthopedic and dental applications.

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Publication details

The article was received on 08 Nov 2017, accepted on 08 Feb 2018 and first published on 09 Feb 2018


Article type: Paper
DOI: 10.1039/C7BM01017F
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    The effects of surface bioactivity and sustained-release of genistein from mesoporous magnesium-calcium-silicate/PK composite stimulating cells responses in vitro, and promoting osteogenesis and enhancing osseointegration in vivo

    L. Cai, J. Zhang, J. Qian, Q. Li, H. Li, Y. Yan, S. Wei, J. Wei and J. Su, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM01017F

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