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Issue 2, 2018
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The effect of ordered and partially ordered surface topography on bone cell responses: a review

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Abstract

Implant surfaces play important roles in regulating protein adsorption and determining subsequent cell responses, including cell attachment, proliferation, migration and differentiation. With rapid developments in micro- and nano-fabrication methods and additive manufacturing (3D printing) technologies, precisely controlled patterns such as partially ordered or ordered patterns can now be generated on bone implant surfaces, rather than restricted to randomly roughened surfaces. Over the last two decades, much effort has been dedicated to manipulating cell responses through surface topographical modifications. This review discusses the recent developments and understanding of surface topography in prompting or enhancing desired cell responses, particularly the roles of ordered and partially ordered surface topography under in vitro conditions. In addition, the challenges to translate research findings into implant applications are addressed.

Graphical abstract: The effect of ordered and partially ordered surface topography on bone cell responses: a review

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Publication details

The article was received on 13 Nov 2017, accepted on 13 Dec 2017 and first published on 14 Dec 2017


Article type: Review Article
DOI: 10.1039/C7BM01016H
Citation: Biomater. Sci., 2018,6, 250-264
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    The effect of ordered and partially ordered surface topography on bone cell responses: a review

    N. Gui, W. Xu, D. E. Myers, R. Shukla, H. P. Tang and M. Qian, Biomater. Sci., 2018, 6, 250
    DOI: 10.1039/C7BM01016H

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