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Enhanced cell adhesion on a bio-inspired hierarchically structured polyester modified with gelatin-methacrylate

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Abstract

Herein, fabrication and modification of novel bio-inspired microwell arrays with nanoscale topographic structures are reported. The natural nano- and microstructures present on the surface of rose petals were hypothesized to enhance cell-surface contacts. Thus hierarchically structured polyethylene terephthalate glycol modified (PETG) substrates were fabricated by replication from rose petals via nanoimprint lithography, followed by covalent modification and crosslinking with RGD-presenting gelatin-methacrylate (GelMA) for promoting cell adhesion and spreading. Cell culture experiments showed that the introduction of gelatin resulted in significantly enhanced cell adhesion and more than doubled cell areas on the GelMA modified surfaces. In addition, a slight preference was observed for concave compared to convex surfaces, which is tentatively attributed to the matching curvature of the micro-cavities and the cells, facilitating the accommodation of cells. These bioinspired hierarchically structured and gelatin functionalized substrates may provide new prospects for designing cell-based interfaces for advanced biomedical studies, e.g. for cell culture and biosensing in the future.

Graphical abstract: Enhanced cell adhesion on a bio-inspired hierarchically structured polyester modified with gelatin-methacrylate

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Publication details

The article was received on 30 Oct 2017, accepted on 24 Nov 2017 and first published on 27 Nov 2017


Article type: Paper
DOI: 10.1039/C7BM00991G
Citation: Biomater. Sci., 2018, Advance Article
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    Enhanced cell adhesion on a bio-inspired hierarchically structured polyester modified with gelatin-methacrylate

    P. Li, X. Dou, C. Feng and H. Schönherr, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C7BM00991G

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