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Issue 2, 2018
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Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction

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Abstract

An effective therapy for chronic myocardial infarction (MI) has yet to be developed. Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after MI. However, non-targeted delivery of VEGF decreases its therapeutic efficacy. In this study, for targeting the cardiac extracellular matrix, a collagen-binding domain (CBD) VEGF was used to bind specifically to the collagen-rich cardiac extracellular matrix. When intramyocardially injected into the peri-infarct region of a chronically infarcted porcine heart, CBD-VEGF attenuated the remodeling of the left ventricle with a decreased infarct size and promoted cardiomyocyte survival and angiogenesis 3 months after injection. In the 12-month trial, mature vessel networks and myocardium-like tissues were observed in the infarct region after CBD-VEGF injection. Also these beneficial effects might derive from CBD-VEGF significantly protecting cardiomyocytes from apoptosis and recruiting cardiac progenitor cells to the infarcted region. These results demonstrated that CBD-VEGF could be a promising therapeutic strategy for chronic MI.

Graphical abstract: Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction

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Publication details

The article was received on 30 Sep 2017, accepted on 04 Dec 2017 and first published on 05 Dec 2017


Article type: Paper
DOI: 10.1039/C7BM00891K
Citation: Biomater. Sci., 2018,6, 356-363
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    Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction

    C. Shi, Y. Zhao, Y. Yang, C. Chen, X. Hou, J. Shao, H. Yao, Q. Li, Y. Xia and J. Dai, Biomater. Sci., 2018, 6, 356
    DOI: 10.1039/C7BM00891K

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